中国发明专利：基于光控流体运输、磁控样品分离的蛋白质富集检测装置

发明（设计）人：竺翀宇，俞燕蕾，鲁遥

申请人：复旦大学

专利号：ZL 202010531798.8

摘要：

本发明涉及基于光控流体运输、磁控样品分离的蛋白质富集检测装置，光流控微管执行器内部用于容纳磁性纳米粒子、待检测液体样品、检测液，并是磁性纳米粒子捕获目标蛋白，以及目标蛋白与检测液发生反应的场所，所述电磁控制装置置于光流控微管执行器的外部中间位置，通过控制电源开闭实现磁场的施加与撤销；控制光源置于光流控微管执行器的外部上方，用于驱动光流控微管执行器内的液体完成定向移动；检测管与光流控微管执行器一端连接，光学检测仪器用于进行检测管内液体的光学检测。与现有技术相比，本发明可以实现非接触操控，并能真正实现便携化的蛋白检测，同时也有效避免了样品被污染的风险。

Abstract：

The invention relates to a protein enrichment detection device based on light-operated fluid transportation and magnetic control sample separation. The interior of an optical flow control micro-tube actuator is used for accommodating magnetic nanoparticles, a to-be-detected liquid sample and a detection liquid and is a place for capturing the target protein of magnetic nano particles and reactionbetween the target protein and detection liquid. An electromagnetic control device is arranged in the middle of the exterior of the optical flow control micro-tube actuator, and exertion and cancellation of a magnetic field are achieved by controlling on-off of a power supply; a control light source is arranged above the outer part of the optical flow control micro-tube actuator and is used for driving liquid in the optical flow control micro-tube actuator to finish directional movement; the detection tube is connected with one end of the optical flow control micro-tube actuator, and the optical detection instrument is used for optical detection of liquid in the detection tube. Compared with the prior art, non-contact control can be achieved, portable protein detection can be truly achieved, and meanwhile the risk that a sample is polluted is effectively avoided.