中国发明专利：微流控芯片及其制备方法、微流体驱动方法

发明（设计）人：俞燕蕾; 姜黎新; 江雨萌; 韦嘉

申请人：复旦大学

专利号：ZL 2025 1 0745551.9

摘要：

本发明公开了一种微流控芯片，包括：基板，由光致形变交联型液晶高分子材料制成，包括第一表面，第一表面上开设有凹槽，凹槽顶部设有槽口；薄膜，由光致形变线型液晶高分子材料制成，贴附于第一表面并覆盖所述槽口，凹槽与覆盖槽口的薄膜包围形成微通道，微通道用于运输微流体；其中，微通道的一部分被光照射时，该微通道形成光照区通道和非光照区通道，光照区通道的凹槽和薄膜发生形变，使得光照区通道的横截面面积大于非光照区通道的横截面面积，从而驱动光照区通道中的微流体向非光照区通道流动。利用凹槽和薄膜的共同形变，增大微通道形变量，显著提升对微流体的驱动力。本发明还公开了微流控芯片制备方法、微流体驱动方法。

Abstract:
The invention discloses a microfluidic chip, comprising: a substrate, made of a photodeformable crosslinked liquid crystal polymer material, including a first surface, in which a groove is on the first surface, and a slot opening is provided at the top of the groove; and a film, made of a photodeformable linear liquid crystal polymer material, attached to the first surface and covering the slot opening, wherein the groove and the film covering the slot opening enclose a microchannel, and the microchannel is used for transporting microfluids. When a portion of the microchannel is irradiated with light, the microchannel forms an illuminated zone channel and a non-illuminated zone channel; the groove and the film in the illuminated zone channel undergo deformation, such that the cross-sectional area of the illuminated zone channel is larger than that of the non-illuminated zone channel, thereby driving the microfluid in the illuminated zone channel to flow toward the non-illuminated zone channel. By utilizing the co-deformation of the groove and the film, the deformation magnitude of the microchannel is increased, significantly enhancing the driving force on the microfluid. The present invention also discloses a method for preparing the microfluidic chip and driving microfluids.